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Department of Chemical and Biological Engineering Chris Brazel's Research, Teaching and Resources Website |
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Research Interests and Biography Publications
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PUBLICATIONS Recent publications have focused on the research areas of modeling in controlled release and the burst effect, polymerizations in environmentally benign ionic liquids, biosensors, and cardiovascular delivery methods. Recent Publication List (1999-2006): Brazel, C.S. and N.A. Peppas. “Mechanisms of Solute and Drug Transport in Relaxing Swellable Hydrophilic Glassy Polymers,” Polymer, 40 (1999) 3383-3398.
Brazel, C.S. and N.A. Peppas. “Dimensionless Analysis of Swelling of Hydrophilic Glassy Polymers with Subsequent Drug Release from Relaxing Structures,” Biomaterials, 20 (1999) 721-732.
Brazel, C.S. “Microencapsulation: Offering Solutions in the Food Industry,” Cereal Foods World, 44 (1999) 388-393.
Marshall, M.C., S. Wellinghoff, C. Brazel, M. Alexander and S. Akatagawa, “Controlled Delivery of Pesticides through Synthetic Biodegradable Polymer Compositions”, in H. Scher, ed. Controlled Release Delivery Systems for Pesticides, New York: Marcel Dekker, Inc., 1999, 363-394.
Brazel, C.S. and N.A. Peppas. “Modelling of Drug Release from Swellable Polymers,” Eur. J. Pharm. and Biopharm., 49 (2000) 47-58.
Brazel, C.S. and N.A. Peppas, “Recent Studies and Molecular Analysis of Drug Release from Swelling-Controlled Devices,” STP Pharma Sci. 9 (1999) 473-485.
Colombo, P., P. Santi, R. Bettini, C.S. Brazel, and N.A. Peppas, “Drug Release from Swelling-Controlled Systems,” in D.L. Wise et al., eds. Handbook of Pharmaceutical Controlled Release Technology, New York: Marcel Dekker, Inc. (2000) 183-210.
Brazel, C.S. “Biomedical Sensing by the use of Intelligent Polymers,” in A. Biderman, ed. Encyclopedia of Smart Materials, in press.
Huang, X. and C.S. Brazel, “On the Importance and Mechanisms of Burst Release in Controlled Drug Delivery- A Review,” J. Control. Rel., 73 (2001) 121-136.
Thornton, A.M. and C.S. Brazel, “Design of pH Sensitive Materials for On/Off Release of Thrombolytic and Anticoagulant Drugs,” in S. Mallapragada, M. Tracy, B. Narasimhan, E. Mathiowitz, and R. Korsmeyer, eds., Biomaterials for Drug Delivery and Tissue Engineering, Warrendale, PA: Materials Research Society, Pittsburgh, 662 (2000) MM2.6.1-MM2.6.6. Huang, X. and C.S. Brazel, “Analysis of Burst Release of Proxyphylline from Poly(vinyl alcohol) Hydrogels,” Chemical Engineering Communications, 190 (2003) 519-532.
Benton, M.G. and C.S. Brazel, “Effect of Room Temperature Ionic Liquids as Replacements for Volatile Organic Solvents in Free Radical Polymerization,” in Rogers, R.D. and K.R. Seddon, eds., Ionic Liquids: Industrial Applications for Green Chemistry, Washington, DC: American Chemical Society Symposium Series 818 (2002) 125-133.
Stoltz, M.J. and C.S. Brazel, ““Novel Dual Temperature Sensitive Materials Based on Interpenetrating Polyalkylacrylamide Networks for Temperature-Proportional Controlled Release,” Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 28 (2001) #0512.
Brazel, C.S. “Integrating Team Laboratory Experiments Into a Senior Biochemical Engineering Course,” Proceed. American Society for Engineering Education Annual Conference, paper 194 (2002) 1-16.
Brazel, C.S., G.S. Maddox, M.F. Garcia, L.M. Savoy, M.G. Benton, and A.M. Thornton, “Fundamental Chemical Differences between Polyacidic and Polybasic Materials for the Design of pH-Responsive Systems,” Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 29 (2002) #007
Huang, X. and C.S. Brazel, “Understanding the Burst Effect: Release in PVA Hydrogel Systems, Improvements in Modeling, and Approaches to Preventing Burst,” Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 29 (2002) #236
Hong, K., H. Zhang, J.W. Mays, A.E. Visser, C.S. Brazel, J.D. Holbrey, W.M. Reichert, and R.D. Rogers, “Conventional Free Radical Polymerization in Room Temperature Ionic Liquids: A Green Approach to Commodity Polymers with Practical Advantages,” Chem. Comm., 2002 (2002) 1368-1369.
Huang, X., B.L. Chestang, and C.S. Brazel, "Minimization of Initial Burst in Poly(vinyl alcohol) Hydrogels by Surface Extraction and Surface-Preferential Crosslinking," Int. J. Pharm. 248 (2002) 183-192.
Stoltz, M.J. and C.S. Brazel, “Dual-LCST Polymer Networks Based on Block, Laminate, and Interpenetrating Network Structures Composed of N-Alkylacrylamides, and N,N-Dialkylaminoethyl Methacrylates,” J. Appl. Polym. Sci., 88 (2003) 2974-2981.
Scott, M.P., C.S. Brazel, M.G. Benton, J.W. Mays, J. D. Holbrey, and R.D. Rogers, “Application of Ionic Liquids as Plasticizers for Poly(methyl methacrylate),” Chem. Comm., 2002 (2002) 1370-1371.
Brazel, C.S. and X. Huang, ”The Cost of Optimal Drug Delivery: Reducing and Preventing the Burst Effect in Matrix Systems,” Svenson, S., ed. Carrier-Based Drug Delivery, ACS Symposium Series, Washington, DC: American Chemical Society 879 (2004) 267-282.
Brazel, C.S., A.N. Roberts, and X. Huang, “Surface-Preferential Crosslinking in Hydrogels to Minimize The Burst Effect and Design Tunable Lag Times for Drug Delivery,” IEEE Trans. Biomed. Eng., 2 (2002) 496-497.
Scott, M.P., M.G. Benton, M. Rahman, and C.S. Brazel, “Plasticizing Effects of Imidazolium Salts in PMMA: High Temperature Stable Flexible Engineering Materials,” in Rogers, R.D., and K.R. Seddon, eds. Ionic Liquids as Green Solvents: Progress and Prospects, Washington, DC: American Chemical Society Symposium Series, 856 (2003) 468-477.
Benton, M.G. and C.S. Brazel, “Comparison of Kinetics For Solution Polymerization of Poly(methyl methacrylate) in Green Ionic Liquid Solvents Versus Traditional Volatile Solvents,” Polym. Prepr. 43 (2002) 881-882.
Scott, M.P., M. Rahman and C.S. Brazel, “Application of Ionic Liquids as Low Volatility Plasticizers for PMMA,”Eur. Polym. J. 39 (2003) 1947-1953.
Benton, M.G. and C.S. Brazel, “An Investigation of the Degree and Rate of Polymerization of Poly(methyl methacrylate) in the Ionic Liquid 1-Butyl-3-Methylimidazolium Hexafluorophosphate,” Polymer International 53 (2004) 1113-1117.
Brazel, C.S. “Book Review: Polymeric Drugs and Drug Delivery Systems,” J. Control. Rel., 89 (2003) 143.
Carroll, K.S., J.B. McKinney, D.T. Johnson and C.S. Brazel, “Development of Magnetothermal Responsive Systems for Tumor Treatment,” Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 30 (2003), #082.
Rahman, M., M.G. Benton, M.P. Scott and C.S. Brazel, “Room Temperature Ionic Liquids as Environmentally Benign Plasticizers and Reaction Media for Polymerization Reactions,” Proceed. Green Chem. Eng. Conf. 7 (2003) 180-183.
Brazel, C.S., D.W. Arnold, G.C. April, A.M. Lane, J.M. Wiest, “Chemical Engineering at The University of Alabama,” Chemical Engineering Education 38 (2004) 8-13.
Rahman, M. and C.S. Brazel, “Effectiveness of Phosphonium, Ammonium, and Imidazolium-Based Ionic Liquids as Plasticizers for Poly(vinyl chloride): Thermal and Ultraviolet Stability,” Polym. Prepr. 45-1 (2004) 301-302.
Shoff, H.W., M. Rahman, and C.S. Brazel, “Leaching and Migration Resistance of Phosphonium- Based Ionic Liquids as PVC Plasticizers: A Comparative Study of Traditional Phthalate and Citrate Plasticizers with Ionic Liquids,” Polym. Prepr. 45-1 (2004) 295-296.
Rahman, M. and C.S. Brazel, “Review: An Assessment of Traditional Plasticizers and Research Trends for Development of Novel Plasticizers,” Prog. Polym. Sci., 29 (2004), 1223-1248.
Rahman, M., H.W. Shoff and C.S. Brazel, “Ionic Liquids as Alternative Plasticizers for PVC: Flexibility and Stability in Thermal, Leaching and Ultraviolet Environments,” in Brazel, C.S. and R.D. Rogers, eds. Ionic Liquids in Polymer Systems: Solvents, Additives, and Novel Application, Washington, D.C.: American Chemical Society Symposium Series, 913 (2005), 103-118.
Brazel, C.S. and R.D. Rogers, “Preface: Ionic Liquids in Polymer Systems,” in Brazel, C.S. and R.D. Rogers, eds. Ionic Liquids in Polymer Systems: Solvents, Additives, and Novel Applications, Washington, D.C.: American Chemical Society Symposium Series, 913 (2005) ix-x.
Brazel, C.S., “Review of Reflexive Polymers & Hydrogels: Understanding and Designing Fast Responsive Polymeric Systems by N. Yui, R.J. Mrsny, and K. Park, Boca Raton, FL: CRC Press” J.ACS, 127 (2005) 1590.
Saini, V., V.P. Zharov, C.S. Brazel, D.E. Nikles, D.T. Johnson and M. Everts, “Combination of Viral Biology and Nanotechnology: New Applications in Nanomedicine,” Nanomedicine, in press.
Rahman, M. and C.S. Brazel, “Ionic Liquids: New Generation Stable Plasticizers for Poly(vinyl chloride),” Polymer Degradation and Stability, 2006, in press.
Brazel, C.S., P.E. Clark, T.M. Klein, A.M. Lane, and S.M.C. Ritchie, “Renovation and Upgrades of Chemical and Biological Engineering Unit Operations Lab to Teach Technical Skills in Emerging Engineering Fields,” ASEE-Southeast Regional Meeting, paper # 37.
Wu, L.F. and C.S. Brazel, “Extending Surface Crosslinking Technique to Prevent the Burst Effect to Controlled Release Systems Based on Poly(vinyl alcohol), Poly(2-hydroxyethyl methacrylate), and Gelatin,” Control. Rel. Soc. Trans., 33 (2006), #234.
Brazel, C.S., I. Ankareddi, M.L. Hampel, H. Bagaria, D.T. Johnson, and D.E. Nikles, “Development of Magnetothermal-Responsive Delivery Systems Using FePt Nanoparticles Imbedded in Poly(N-isopropylacrylamide)-Based Hydrogels,” Control. Rel. Soc. Trans., 33 (2006), #762.
For a complete list, view the Curriculum Vita.
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