Research summary

My research focuses on mathematical/statistical modeling and algorithm developing in biomedical image processing as well as analysis. The image processing part includes but not limit to smoothing, segmentation, registration and fusion of various medical images: those of different organs from different modalities, including scalar images and vector-valued images. In particular, ultrasound and MRI cardiac images, T1,T2,FLAIR MRI human brain images are discovered in length. The image analysis part focuses on diffusion weighted Magnetic Resonance Imaging, topics of which include human brain white matter fiber tract reconstruction; recovery of intra-voxel structure; classification of intra-voxel diffusion; estimation, smoothing and characterization of apparent diffusion coefficient profiles. See Publications for complete list and links to papers. Some example projects are shown below.

Simultaneous smoothing and segmentation[Paper 1 2 3]

Raw human echocardiographic 

Smoothed echocardiographic image

Segmentation of the heart

Raw FLAIR MRI human brain image

Segmentation of hyper-intensity(disease)

A movie shows procedure of segmentation

Smoothing of Partially Parallel Imaging Data[Paper 1 2]

Noisy human cardiac MRI data (GRAPPA PPI)

Regulating version

Smoothed result

Fuse Different Reconstruction for Better PPI images[Paper]

GRAPPA reconstruction (with more noise)

mSENSE reconstruction (with more artifacts)

Combined results (with less noise and less artifacts)

Diffusion Tensor Image Segmentation[Paper 1 2]

3D Segmentation of Corpus Callosum

Motivation

2D contour of Corpus Callosum superimposed on FA image

Human Brain White Matter Fiber Tract Reconstruction from Diffusion Weightd MRI[Paper 1 2]

Literature result of tracts passing through the region of interest

Red: Region of Interest(ROI)

Our result of tracts passing through the ROI

Fiber tracts near Corpus Callosum, embedded in the whole brain (Axial view)

Coronal view

Saggital view

Recovery of Intra-Voxel structure from Diffusion weighted MRI[Paper]
Color pie Color coding of the first fibers in one slice of a human brain Color coding of the second fibers in one slice of a human brain

Reconstruction and smoothing of ADC in Diffusion Weighted MRI[Paper 1 2]

  R2 maps of least square (left) and our results (middle); Right: classification of voxels: white (2-fiber), gray(1-fiber), black(isotropic).

Figures of ADC at three voxels (from top to bottom) before (first column) and after (second column) smoothing